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Detecting genetic hypermutability of gastrointestinal tumor by using a forensic STR kit

Anqi Chen, Suhua Zhang, Jixi Li, Chaoneng Ji, Jinzhong Chen, Chengtao Li

Frontiers of Medicine 2020, Volume 14, Issue 1,   Pages 101-111 doi: 10.1007/s11684-019-0698-4

Abstract: Growing evidence suggests that somatic hypermutational status and programmed cell death-1 overexpression are potential predictive biomarkers indicating treatment benefits from immunotherapy using immune checkpoint inhibitors. However, biomarker-matched trials are still limited, and many of the genomic alterations remain difficult to target. To isolate the potential somatic hypermutational tumor from microsatellite instability low/microsatellite stability (MSI-L/MSS) cases, we employed two commercial kits to determine MSI and forensic short tandem repeat (STR) alternations in 250 gastrointestinal (GI) tumors. Three types of forensic STR alternations, namely, allelic loss, Aadd, and Anew, were identified. 62.4% (156/250) of the patients with GI exhibited STR alternation, including 100% (15/15) and 60% (141/235) of the microsatellite high instability and MSI-L/MSS cases, respectively. 30% (75/250) of the patients exhibited STR instability with more than 26.32% (26.32%–84.21%) STR alternation. The cutoff with 26.32% of the STR alternations covered all 15 MSI cases and suggested that it might be a potential threshold. Given the similar mechanism of the mutations of MSI and forensic STR, the widely used forensic identifier STR kit might provide potential usage for identifying hypermutational status in GI cancers.

Keywords： mismatch repair protein deficiency (MMR-D)     microsatellite instability (MSI)     short tandem repeats (STR    

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Expression status of GATA3 and mismatch repair proteins in upper tract urothelial carcinoma

Yue Wang, Jinxia Zhang, Yunfan Wang, Shufang Wang, Yu Zhang, Qi Miao, Fei Gao, Huiying He

Frontiers of Medicine 2019, Volume 13, Issue 6,   Pages 730-740 doi: 10.1007/s11684-019-0687-7

Abstract: GATA binding protein 3 (GATA3) and mismatch repair (MMR) deficiency contribute to the development ofHere, we immunohistochemically stained GATA3 and MMR proteins in 108 UTUC samples.The absence of MMR proteins was observed in 8.3% of the cases, and focal staining was identified in 13.0%When using “lax criteria” which resulted in counting cases as negative where MMR staining was in fact

Keywords： upper tract urothelial carcinoma     GATA binding protein 3     mismatch repair     microsatellite instability     prognosis    

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Antithrombin deficiency and decreased protein C activity in a young man with venous thromboembolism:

Dong Wang, Min Tian, Guanglin Cui, Dao Wen Wang

Frontiers of Medicine 2018, Volume 12, Issue 3,   Pages 319-323 doi: 10.1007/s11684-017-0553-4

Abstract:

Antithrombin and protein C are two crucial members in the anticoagulant system and play importantMutations in and lead to deficiency or dysfunction of the two proteins, which could result in venousCoagulation tests revealed that the patient presented type I antithrombin deficiency combined with decreasedprotein C activity resulting from a small insertion mutation c.848_849insGATGT in and a short deletionThis study demonstrates that the combination of antithrombin deficiency and decreased protein C activity

Keywords： antithrombin deficiency     protein C activity     mutation     variant     venous thromboembolism     anticoagulants    

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Prevalence of vitamin D deficiency in girls with idiopathic central precocious puberty

Yue Zhao, Wenjun Long, Caiqi Du, Huanhuan Yang, Shimin Wu, Qin Ning, Xiaoping Luo

Frontiers of Medicine 2018, Volume 12, Issue 2,   Pages 174-181 doi: 10.1007/s11684-017-0544-5

Abstract:

The relationship between vitamin D deficiency and idiopathic central precocious puberty (ICPP) hasThe ICPP group had significantly lower serum 25-hydroxyvitamin D (25[OH]D) levels than the control groupFurthermore, a nonlinear relationship was found between serum 25[OH]D and ICPP, and a cut-off point forserum 25[OH]D was found at 31.8 ng/ml for ICPP with and without adjusting the different confoundingThe ICPP subjects with 25[OH]D deficiency had a higher body mass index (BMI) than the subjects from the

Keywords： idiopathic central precocious puberty     threshold effects     vitamin D status    

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Correlativity study between expression of DNA double-strand break repair protein and radiosensitivity

Liang ZHUANG, Shiying YU, Xiaoyuan HUANG, Yang CAO, Huihua XIONG

Frontiers of Medicine 2009, Volume 3, Issue 1,   Pages 26-29 doi: 10.1007/s11684-009-0008-7

Abstract: DNA-PK catalytic subunit (DNA-PKcs) and ataxia telangiectasia mutated (ATM) proteins are major DSB repairclone formation assay, and western blot was applied to detect the expressions of Ku80, DNA-PKcs and ATM proteinThe correlativity of protein expression with SF2 value was analyzed by Pearson linear correlation analysisWe found that the expression of same protein in different cell lines and the expression of three proteinsThese findings suggest that the expression level of DNA-PKcs protein can be an indicator for predicting

Keywords： Ku80     DNA-PK(cs)-binding protein     human     ataxia telangiectasia mutated protein     tumor cell lines     radiosensitivity    

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Decellularized extracellular matrix mediates tissue construction and regeneration

Frontiers of Medicine 2022, Volume 16, Issue 1,   Pages 56-82 doi: 10.1007/s11684-021-0900-3

Abstract: tissue regeneration, extracellular matrix (ECM) constituents provide tissue with three-dimensional (3D)substitutes mediate cell–matrix interactions to prompt stem-cell proliferation and differentiation for 3Dare often applied generically and have yet to be extensively developed for specific cell types in 3DCellular ECM improves 3D culture development in vitro and tissue remodeling during wound healingorgan regeneration helps us to select, produce, and implant the most suitable ECM and thus promote 3D

Keywords： decellularized extracellular matrix     3D culture     organoids     tissue repair    

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PROTECTIVE ROLES OF D1 PROTEIN TURNOVER AND THE XANTHOPHYLL CYCLE IN TOMATO (SOLANUM LYCOPERSICUM) UNDER

Frontiers of Agricultural Science and Engineering 2021, Volume 8, Issue 2,

Abstract:

D1 protein turnover and the xanthophyll cycle (XC) are important photoprotective mechanisms in plantsHere, streptomycin sulfate (SM) and dithiothreitol (DTT) were used in tomato plants as inhibitors of D1protein turnover and XC to elucidate their photoprotective impacts under sub-high temperature and highprotein production at both transcriptional and translational levels.Overall, inhibition of D1 turnover caused greater photoinhibition than XC inhibition.

Keywords： D1 turnover / photoinhibition / photoprotection / photosynthesis / tomato / xanthophyll cycle    

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PROTECTIVE ROLES OF D1 PROTEIN TURNOVER AND THE XANTHOPHYLL CYCLE IN TOMATO (

Tao LU, Jiazhi LU, Mingfang QI, Zhouping SUN, Yufeng LIU, Tianlai LI

Frontiers of Agricultural Science and Engineering   Pages 262-279 doi: 10.15302/J-FASE-2021383

Abstract: D1 protein turnover and the xanthophyll cycle (XC) are important photoprotective mechanisms in plantsHere, streptomycin sulfate (SM) and dithiothreitol (DTT) were used in tomato plants as inhibitors of D1protein turnover and XC to elucidate their photoprotective impacts under sub-high temperature and highprotein production at both transcriptional and translational levels.Overall, inhibition of D1 turnover caused greater photoinhibition than XC inhibition.

Keywords： D1 turnover     photoinhibition     photoprotection     photosynthesis     tomato     xanthophyll cycle    

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Dynein axonemal heavy chain 10 deficiency causes primary ciliary dyskinesia in humans and mice

Frontiers of Medicine   Pages 957-971 doi: 10.1007/s11684-023-0988-8

Abstract: To the best of our knowledge, this study is the first to report DNAH10 deficiency related to PCD

Keywords： DNAH10     mice     motile cilia     mutation     primary ciliary dyskinesia    

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Generation and repair of AID-initiated DNA lesions in B lymphocytes

Zhangguo Chen,Jing H. Wang

Frontiers of Medicine 2014, Volume 8, Issue 2,   Pages 201-216 doi: 10.1007/s11684-014-0324-4

Abstract: AID induces U:G mismatch lesions in DNA that are subsequently converted into point mutations or DNA doublereview, we focus on the molecular mechanisms that regulate the specificity of AID targeting and the repair

Keywords： class switch recombination     somatic hypermutation     activation-induced deaminase     DNA repair     genomic instability    

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Construction of a CaHPO4-PGUS1 hybrid nanoflower through protein-inorganic self-assembly, and its applicationin glycyrrhetinic acid 3-O-mono-β-D-glucuronide preparation

Tian Jiang, Yuhui Hou, Tengjiang Zhang, Xudong Feng, Chun Li

Frontiers of Chemical Science and Engineering 2019, Volume 13, Issue 3,   Pages 554-562 doi: 10.1007/s11705-019-1834-z

Abstract: Glycyrrhetinic acid 3- -mono- -D-glucuronide (GAMG), an important pharmaceutical intermediate and functionalmethod was established to prepare a CaHPO -PGUS1 hybrid nanoflower for enzyme immobilization, based on protein-inorganic

Keywords： enzyme-inorganic hybrid nanoflower     biotransformation     glycyrrhizin     glycyrrtinic acid 3-O-mono-β-D-glucuronide    

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Bile duct injury repair — earlier is not better

Vinay K. Kapoor

Frontiers of Medicine 2015, Volume 9, Issue 4,   Pages 508-511 doi: 10.1007/s11684-015-0418-7

Abstract: The timing of bile duct injury repair remains controversial.A recent review conducted in France reported 39% complications and 64% failure after immediate repairin 194 patients compared with 14% complications and 8% failure after late repair in 133 patients.Most patients with bile duct injury present with bile leak and sepsis; thus, early repair is not recommended

Keywords： bile duct injury     cholecystectomy     laparoscopic cholecystectomy    

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non-inferiority trial of intravenous ferric carboxymaltose versus iron sucrose in patients with iron deficiency

Frontiers of Medicine doi: 10.1007/s11684-023-1001-2

Abstract: Iron deficiency (ID) and ID anemia (IDA) pose significant public health concerns in China.

Keywords： iron deficiency     anemia     intravenous iron     ferric carboxymaltose     iron sucrose     Hb response     early response    

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Mobile platform for hydraulic turbine blade repair robot

GUI Zhongcheng, CHEN Qiang, SUN Zhenguo, ZHANG Wenzeng, LIU Kang

Frontiers of Mechanical Engineering 2008, Volume 3, Issue 2,   Pages 164-169 doi: 10.1007/s11465-008-0035-0

Abstract: adapt to complex spatial surfaces, which satisfy the requirements of a hydraulic turbine blade in-situ repair
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The effects of mismatch fracture properties in encapsulation-based self-healing concrete using cohesive-zone

Luthfi Muhammad MAULUDIN, Chahmi OUCIF, Timon RABCZUK

Frontiers of Structural and Civil Engineering 2020, Volume 14, Issue 3,   Pages 792-801 doi: 10.1007/s11709-020-0629-0

Abstract: A 2D circular capsule with different core-shell thickness ratios embedded in the mortar matrix is analyzedThis study focuses on the effects of mismatch fracture properties, namely fracture strength and energyThe extensive simulations of 2D specimens under uniaxial tension were carried out to investigate the

Keywords： self-healing concrete     interfacial zone     capsule materials     cohesive elements     fracture maps    

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Title Author Date Type Operation

Detecting genetic hypermutability of gastrointestinal tumor by using a forensic STR kit

Anqi Chen, Suhua Zhang, Jixi Li, Chaoneng Ji, Jinzhong Chen, Chengtao Li

Journal Article

Expression status of GATA3 and mismatch repair proteins in upper tract urothelial carcinoma

Yue Wang, Jinxia Zhang, Yunfan Wang, Shufang Wang, Yu Zhang, Qi Miao, Fei Gao, Huiying He

Journal Article

Antithrombin deficiency and decreased protein C activity in a young man with venous thromboembolism:

Dong Wang, Min Tian, Guanglin Cui, Dao Wen Wang

Journal Article

Prevalence of vitamin D deficiency in girls with idiopathic central precocious puberty

Yue Zhao, Wenjun Long, Caiqi Du, Huanhuan Yang, Shimin Wu, Qin Ning, Xiaoping Luo

Journal Article

Correlativity study between expression of DNA double-strand break repair protein and radiosensitivity

Liang ZHUANG, Shiying YU, Xiaoyuan HUANG, Yang CAO, Huihua XIONG

Journal Article

Decellularized extracellular matrix mediates tissue construction and regeneration

Journal Article

PROTECTIVE ROLES OF D1 PROTEIN TURNOVER AND THE XANTHOPHYLL CYCLE IN TOMATO (SOLANUM LYCOPERSICUM) UNDER

Journal Article

PROTECTIVE ROLES OF D1 PROTEIN TURNOVER AND THE XANTHOPHYLL CYCLE IN TOMATO (

Tao LU, Jiazhi LU, Mingfang QI, Zhouping SUN, Yufeng LIU, Tianlai LI

Journal Article

Dynein axonemal heavy chain 10 deficiency causes primary ciliary dyskinesia in humans and mice

Journal Article

Generation and repair of AID-initiated DNA lesions in B lymphocytes

Zhangguo Chen,Jing H. Wang

Journal Article

Construction of a CaHPO4-PGUS1 hybrid nanoflower through protein-inorganic self-assembly, and its applicationin glycyrrhetinic acid 3-O-mono-β-D-glucuronide preparation

Tian Jiang, Yuhui Hou, Tengjiang Zhang, Xudong Feng, Chun Li

Journal Article

Bile duct injury repair — earlier is not better

Vinay K. Kapoor

Journal Article

non-inferiority trial of intravenous ferric carboxymaltose versus iron sucrose in patients with iron deficiency

Journal Article

Mobile platform for hydraulic turbine blade repair robot

GUI Zhongcheng, CHEN Qiang, SUN Zhenguo, ZHANG Wenzeng, LIU Kang

Journal Article

The effects of mismatch fracture properties in encapsulation-based self-healing concrete using cohesive-zone

Luthfi Muhammad MAULUDIN, Chahmi OUCIF, Timon RABCZUK

Journal Article